This is the fourth Learning Brief in a series of Learning Briefs produced by Isandla Institute under the Safer Places: Resilient Institutions and Neighbourhoods Together (SPRINT) Project. The Learning Brief is produced from the discussions at the fourth Learning Network session, hosted by Isandla Institute on 18 February 2021, and the focus of this brief is Gender, safety and VPIs. The brief introduces a definition of gender that is broad and inclusive. Defining gender-based violence (GBV), and identifying the various types of GBV enables a greater understanding of how GBV manifests. The brief also draws on the reflections of participating CSOs to examine responses to GBV. This includes utilising the socio-ecological model as a key tool to better understand the factors that contribute to GBV allows for more targeted violence prevention interventions (VPIs) that respond to these. One of the key messages of the brief is Placing gender at the centre of VPIs should be prioritised, particularly in light of the significant impact of COVID-19.